L’acide valproïque, antiépileptique largement prescrit, peut être à l’origine d’ intoxications graves. Après avoir décrit un cas d’intoxication sévère avec. Publisher: Selon des sources tertiaires, la prise concomitante de lorazépam et d’ acide valproïque causerait une interaction médicamenteuse. Ici, nous rapportons un cas rare de SJS déclenché par une combinaison de clobazam, la lamotrigine et l’acide valproïque chez un garçon de 7.

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Antiepileptic drugs AEDs are used in combination, leading to potential pharmacokinetic or pharmacodynamic interactions, causing more adverse effects than might occur when the AED is taken as monotherapy.

Boyer cJ. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen. Canevet bC. If you want to subscribe to this journal, see our rates You can purchase this item in Pay Per Qcide A chart review was conducted for patients over 18 years of age who were admitted, from September aacide September inclusive, to the psychiatry or neurology service at Vancouver General Hospital, Vancouver, British Columbia, and who received concomitant valproic acid and lorazepam therapy.


Compounds with the same molecular formula Compounds with the same skeleton Use this molecule in a structure search.

Structure incompatible with current estimation method! Top of the page – Article Outline. In addition, extracorporeal techniques appeared in literature useful to enhance valproic acid elimination, although none among these techniques was more effective.

Access to the full text of this article requires a subscription. The proposed mechanism involves inhibition of lorazepam glucuronidation via direct inhibition of uridine 5′-diphosphate-glucuronosyltransferase enzymes by valproic acid.

Acidf Spectra nist ri. Personal information regarding our website’s visitors, including their identity, is confidential. Here, we report a rare case of SJS triggered by a combination of clobazam, lamotrigine and valproic acid in a 7-year-old boy. Molecular Libraries Screening Center Network. Semi-standard non-polar; Column diameter: Journal Publishers via MeSH. As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data.

Web-based Article blog or commentary. Severe valproic acid poisoning: Depakine chrono [Trade name]. You may thus request that your data, should valproiaue be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. You can move this window by clicking on the headline. Four weeks after the addition of clobazam, the patient developed SJS with a generalized rash, fever, with liver and kidney involvement, and eosinophilia one week after the initiation of treatment.


Coadministration of lorazepam and valproic acid is identified by tertiary references as causing a major drug interaction that requires therapy modification and dosage adjustments.

Acidose lactique sur intoxication volontaire à l’acide valproïque – EM|consulte

Depakote ER [Trade name]. Click to predict properties on the Chemicalize site. Journal page Archives Contents list. Outline Masquer le plan. Valproic acid, Poisoning, Extracorporeal removal enhancement, l -carnitine, Antidote, Hemodialysis. Epival valproiqye [Trade name]. Previous Article Intoxication par le chloralose: Rate constants can NOT be estimated for this structure! Access to the text HTML.

WO1981000562A1 – Sel melange d’acide valproique – Google Patents

Access to the PDF text. Kyselina 2-propylva lerova [Czech]. Alluin bJ.